منابع مشابه
Dengue Vaccines.
The uniqueness of the dengue viruses (DENVs) and the spectrum of disease resulting from infection have made dengue vaccine development difficult. Several vaccine candidates are currently being evaluated in clinical studies. The candidate currently at the most advanced clinical development stage, a live-attenuated tetravalent vaccine based on the chimeric yellow fever-dengue virus (CYD-TDV), has...
متن کاملDengue vaccines: Problems & prospects
639 Dengue virus (DV) infect ion is most ly asymptotic or produces a mild self-limiting acute febrile illness, dengue fever (DF), and a lifethreatening severe illness, dengue haemorrhagic fever (DHF) with minor or major bleeding from different sites. DHF has emerged as the most important arbovirus disease in man in the last three decades. It has been estimated that about 50 to 100 million cases...
متن کاملDengue Vaccines: Challenge and Confrontation
Dengue has been recognized as one of the most important vector-borne human diseases. The disease is induced by dengue virus infection resulting from the bite of an infected Aedes spp. mosquito after imbibing the tainted blood from animals or patients. Dynamic clinical spectrums ranging from asymptomatic, undifferentiated fever, typical dengue fever (DF), dengue hemorrhagic fever (DHF) and dengu...
متن کاملDevelopment of dengue DNA vaccines.
Vaccination with plasmid DNA against infectious pathogens including dengue is an active area of investigation. By design, DNA vaccines are able to elicit both antibody responses and cellular immune responses capable of mediating long-term protection. Great technical improvements have been made in dengue DNA vaccine constructs and trials are underway to study these in the clinic. The scope of th...
متن کاملControlling Dengue with Vaccines in Thailand
BACKGROUND Dengue is a mosquito-borne infectious disease that constitutes a growing global threat with the habitat expansion of its vectors Aedes aegyti and A. albopictus and increasing urbanization. With no effective treatment and limited success of vector control, dengue vaccines constitute the best control measure for the foreseeable future. With four interacting dengue serotypes, the develo...
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ژورنال
عنوان ژورنال: Microbiology Australia
سال: 2011
ISSN: 1324-4272
DOI: 10.1071/ma11128